Outreach

Uterus transplant programs across the US have led to dozens of healthy births. A new review published in Obstetrics & Gynecology summarizes the outcomes from 60 uterus transplants that took place over the course of a decade at the four U.S. locations offering the procedure. It includes data on outcomes for surgical, reproductive, neonatal, and […]

Dr. Jamie Shuda has spent nearly 25 years introducing students to science through Project BioEYES. What started in her own classroom has grown into a remarkable program to bring science into the lives of thousands of students across Philadelphia. Dr. Shuda’s work and BioEYES are a core component of the IRM’s outreach mission. Her programs […]

The Institute for Regenerative Medicine at the University of Pennsylvania is has awarded the 2027 Elaine Redding Brinster Prize in Science or Medicine to Drs. Svetlana Mojsov and Lotte Bjerre Knudsen for the discovery of GLP-1 (7-37) as the physiologically active form of the peptide (Dr. Mojsov) and the development of modified GLP-1 (7-37) that […]

A team of researchers led by IRM faculty member Riccardo Gottardi, PhD, recently published in Nature Communications. Their work explores a novel scaffolding approach to improve surgical treatment of severe subglottic stenosis in infants. Existing surgical treatments for young children are challenging due to the patients lacking the necessary costal cartilage for laryngotracheal reconstruction to […]

A team of researchers led by IRM faculty member Foteini Mourkioti, PhD, have been published in Science Advances for their discovery of a previously unrecognized role for TRF2 in preserving muscle stem cell identity and enabling muscle regeneration. Their findings change how we think about this classic telomere protein and opens new directions for understanding […]

A team of researchers led by IRM faculty member Kotaro Sasaki, PhD, MD, and Eoin Whelan, PhD recently published in Cell Stem Cell on their work to address male infertility.  In the paper, titled Generation of spermatogonia from human and non-human primate pluripotent stem cells, they report on a procedure that allows them to generate […]

The most recent issue of Molecular Cell features a new publication based on a collaboration between Dr. Ken Zaret, IRM Director, and Dr. Yawen Bai of the NIH Center for Cancer Research. Their research assessed how the pioneer factor Ascl1-E12a leverages distinct associations with nucleosomes to open chromatin and reprogram cell fate. The work, published […]

A team of researchers, led by IRM faculty member Dr. Rajan Jain, have been published in Molecular Cell for their research showing that transcription and cohesin play a critical role in the spatial positioning of lamina-associated domain (LAD) boundary genes. Further, they demonstrate that improper positioning of the LAD boundary gene FXN in Friedreich’s ataxia is due […]

The Michalopoulos Endowed Lecture and Award recognizes outstanding scientists whose discoveries and sustained contributions, particularly in areas inspired by Dr. George K. Michalopoulos’s legacy in liver biology, regeneration, and disease, have significantly advanced scientific understanding and continue to influence future generations of researchers. Congratulations to Dr. Zaret for this achievement. You can find more information […]

A team of researchers led by IRM faculty member Kotaro Sasaki, PhD, MD, and Michinori Mayama, PhD, MD, have recently been published in Cell Stem Cell for the development of an organoid system that models the complex tissue structure, development, and function in the developing human adrenal cortex. This work lays the foundation for research on […]