A team of researchers, led by IRM faculty member Dr. Rajan Jain, have been published in Molecular Cell for their research showing that transcription and cohesin play a critical role in the spatial positioning of lamina-associated domain (LAD) boundary genes. Further, they demonstrate that improper positioning of the LAD boundary gene FXN in Friedreich’s ataxia is due to an imbalance between transcription and cohesin dynamics. You can read the full paper here.