A team of researchers led by Hongjun Song, PhD, and Guo-li Ming, MD, PhD (IRM Associate Director), are featured on the cover of the most recent issue of Cell Stem Cell!

In this issue, Shen et al. reveal the critical role of N6-methyladenosine (m⁶A) RNA methylation in hypothalamic neurogenesis using both mouse models and a human-brain-subregion-specific arcuate nucleus organoid (ARCO) model. They further show that defective m⁶A signal leads to aberrant feeding behavior and adult obesity in mice. The cover image highlights the gating of m⁶A in the complex process of differentiating neural stem cells into feeding-related neurons from ARCOs and its impact on feeding behavior and obesity. Cover art by Yu Zhu.